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? ? ? HOME? MEMBERS? CITATIONS? PHOTOS ?LINKS ? ? ? ? ? ? ? ? A brief resume, with selected examples, over 30 years of research?in Organic Synthesis and Natural Products Chemistry from the Lobo-Prabhakar Group. ? ? ? |
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? SYNTHESIZED MOLECULES | ISOLATED COMPOUNDS | PATENTS | SYNTHETIC METHODS | THEORETICAL CHEMISTRY ? ? ? ? |
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| 2004 - Prof. Ana M. Lobo and Prof. S. Prabhakar awarded with the Estímulo à Excelência Award - Excelence in R&D - from the Portuguese Government (Ministerio da Ciência, Inovação e Ensino Superior). | |
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2003 |
Staurosporinone (k-252c) | ? | |
| 2002 |
Benzazepinones ? diltiazem-related Ca2+ antagonists (antiarrhythmic) |
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? Benzoxazinones ? potent insecticides in?gramineous plants ? |
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Benzimidazolones? ? activators of chloride secretion: potential therapeutics for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease |
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? Benzazocinones? ? ? Oxindoles and Pyrazolones |
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| 2001 |
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? (+/-)-Eseroline ? (-)-eseroline is the major metabolite of (-)-physostigmine and possess an analgesic effect similar to that of morphine ? ? ? |
Calabar beans (physostigma venenosum seeds) |
| (-)-Debromoflustramine B |
(Flustra foliacea - marine bryozoan, aquatic colonial animal) |
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| 2000 |
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? ? Tryprostatin B ? cell-cycle progression inhibitor?of tsFT210 (a mutant cell line deficient in Cdc2 kinase) at the G2/M phase barrier ? ? ? ? |
(Aspergillus fumigatus) |
| 1998 |
Diisocyanate, Diurethanes and Diureides ? prepared from dehydroabietic acid, (dehydrogenation of rosin or abietic acid) can be used as industrial monomers for polimer production |
colophony (rosin) |
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1997
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Assoanine | (Amaryllidacea family) |
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? ? Ismine ? Vasconine and Oxoassoanine |
(Amaryllidacea family) | ||
| 1996 | Pratosine | (Amaryllidacea family) | |
| 1995 |
? Arcyriaflavin-A ? inhibition of protein kinase C, platelet aggregation? and citotoxic activity |
(Arcyria denudata) |
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(+/-)-Desoxyeseroline | ? | |
| 1994 | N-substituted amino dihydrocarbostyrils | ? | |
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spiro-gamma-lactams | ? | |
| 1990 |
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Phenanthridines | ? |
| 1989 |
Benzimidazolinones ? activate? cystic fibrosis transmembrane conductance regulator ? (CFTR) |
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| 1987 |
? antitumour, antiviral and anticholinergic activities |
(Amaryllidacea family - crinum spp) |
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| 1982 |
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? Cardenolides Sulphates ? Cardiotonic steroids |
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| 1981 | (+/-)- Alpinigenine | (Papaver Rhoeas) | |
| 1977 | (+/-)-cis - Alpinigenine |
(Papaver Rhoeas) |
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| 1975 |
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? Cardenolides? ? Cardiotonic steroids? allosteric inhibitors of Na+,K+-ATPase (slide: Dr. Kelly Moule) |
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| 1996 |
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Ceramides? |
(Phellinus pini) |
| 1994 | Tetra- and Pentacyclic Triterpenoids |
(Euphorbia piscatoria Ait.) |
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| 1993 |
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Triterpenoids ? |
(Euphorbia mellifera) |
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Triterpenoids and Steroids? |
(Euphorbia peplus) |
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| 1991 | Madeiranes? | ? | |
| 1990 |
Euferol and Melliferol? |
(Euphorbia mellifera) |
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| 1989 | Diterpenoids |
(Salvia Candelabrum) |
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| 1988 | Triterpenoids | (Pisolithus tinctorius) | |
| 1985 | Triterpenoids | (Pisolithus tinctorius) | |
| 1983 | Pisolactone |
(Pisolithus tinctorius) |
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| 2002 |
Fases Estacionarias Quirais Baseadas em Terpenoides ? ? |
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| 1992 |
Diisocyanates, Diurethanes and Diureides from Abietic Acid ? ? |
EP 92670001.4, 11-2-92 |
| 1991 |
Processos para a Obtencao de Novos Derivados de Acidos Resinicos: Diisocianatos, Diuretanos e Diureidos ? |
PT 96748, 11-2-91 |
| 1987 |
Processo para Obtencao de Derivados de Acido Abietico e Composicoes Antimicrobianas desses Derivados ? |
PT 85433, 28-7-87 |
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| 19200384 |
Chemoselective O-desilylation? using SbCl5–wet acetonitrile ? A new efficient method for deprotection of TBDMS derivatives of phenols, primary alcohols, carboxylic acids and secondary amines, consisting of SbCl5 and MeCN with 0.1% water (w/v). It effects inter alia desilylation of a CH2OTBDMS group in the presence of a ketal function. ? ? |
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| 19200184 |
Synthesis of Aziridines? using Palladium(II) and Bromamine T ? The palladium(II)-promoted reaction of a variety of olefins and bromamine T, as the nitrogen atom transfer reagent, provide N-tosyl-2-substituted aziridines under mild conditions. ? |
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| 1997 |
Synthesis of Benzimidazole Derivatives ? from 1-Aza-1´,3´-Diaza-3,3´-Sigmatropic Rearrangements? ? |
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| 1996 |
Enantioselective Synthesis of N-Arylaziridines? by Phase-Transfer Catalysis ? ? |
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| 1995 |
Synthesis of N-Aryl and N-Alkyl-O-Methyl Hydroxylamines ? Trifluoroaceto or p-nitrobenzo-N-substituted hydroxamic acids are smoothly methylated with diazomethane and the products cleanly cleaved by hydrazine. ? |
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| 1994 |
3,3-Sigmatropic Rearrangements using Enehydroxylamines ? ? |
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| 1993 |
Synthesis of Aziridines? using N-Hydroxy-N-pivaloylanilines ? ? |
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| 1992 |
Synthesis of Aminonitrones? from Hydroxylamines and Ethyl Cyanoformate ? ? |
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| 1991 |
Synthesis 3-Substituted N-Benzoyl Oxindoles? using N-Aryl-O-Acyl Hydroxamic Acids ? Selective O-Acylation of Aromatic Hydroxylamines? using 2-Acyl Thiazolium Salts ? ? |
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| 1984 |
Synthesis of N-Hydroxythiobenzamides-(C-Arylhydroxamic Acids)
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| 2005 |
? The CIP System: eliminating ambiguity in the comparison of diastereomorphic and enantiomorphic ligands ? |
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| 1994 |
? Implementation of the Cahn-Ingold-Prelog System for Stereochemical Perception? in the LHASA Program ? |
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| 1993 |
? The CIP Sequence Rules:? Analysis and Proposal for a Revision ? |
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